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Geneious is a cross platform bioinformatics application for Mac OS X, Windows and Linux by Biomatters
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Apache HTTP server is a multi-platform web server for Mac OS X, Windows, Linux and others
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Open Office is a multi-platform office suite for Mac OS X, Windows, Linux and others.
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Blender is a multi-platform 3D graphics creation application, available for Mac OS X, Windows and Linux
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MPlayer is a multi-platform media player, including for Mac OS X, Windows and Linux
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VLC is a media player from VideoLAN for for many operating systems, including Mac OS X, Linux and Windows.
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The GIMP is an Open Source image editor which is a worthy contender to Photoshop. For those inclined it also has a version made to look more like Photoshop, The GimpShop
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FreeCiv is a Civilization type game for Mac and Windows.
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RSSOwl is an Open Source RSS Newsreader
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Firefox is the most popular open source web browser
